With locations all over the Lowcountry and a reliable selection of clothing, cosmetics, and housewares, Belk wins best department store for the tenth year in a row. > Local Runner Up Gwynn’s 916 Houston Northcutt Blvd. Mt. Pleasant (843) 884-9518 gwynns.com This family-owned-and-operated department store, tucked away in a shady Mt. Pleasant shopping center, features high-end clothes, cosmetics, and more. Keep an eye out for their designer trunk shows as well.